Semaphorin-6B (SEMA6B)
Homo sapiens — UniProt Q9H3T3
Data last refreshed: (UniProt release unknown)
Key facts
Semaphorin-6B (SEMA6B) is a protein from Homo sapiens identified by UniProt accession Q9H3T3, 888 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q9H3T3; gene symbol SEMA6B.
- Organism: Homo sapiens.
- Length: 888 amino acids.
- Top disease associations (Open Targets): epilepsy, progressive myoclonic, 11, Intellectual disability and autosomal dominant non-syndromic intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Semaphorin-6B |
|---|---|
| UniProt accession | Q9H3T3 |
| Gene | SEMA6B |
| Organism | Homo sapiens |
| Length | 888 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- epilepsy, progressive myoclonic, 11 · score 0.65
- Intellectual disability · score 0.45
- autosomal dominant non-syndromic intellectual disability · score 0.37
- myoclonic-astatic epilepsy · score 0.27
- visual perception measurement · score 0.19
- genetic disorder · score 0.19
- Neurodevelopmental disorder · score 0.18
- optic cup area measurement · score 0.15
- autism · score 0.12
- isolated cerebellar hypoplasia/agenesis · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3T3-F1 | alphafold | PREDICTED | 73.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3T3.
Amino-acid sequence (888 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SEMA6B?
The strongest Open Targets associations for SEMA6B are epilepsy, progressive myoclonic, 11, Intellectual disability, autosomal dominant non-syndromic intellectual disability, myoclonic-astatic epilepsy and visual perception measurement.
How long is the SEMA6B protein?
The Homo sapiens SEMA6B protein (UniProt Q9H3T3) is 888 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3T3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3T3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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