Protein unc-45 homolog A (UNC45A)
Homo sapiens — UniProt Q9H3U1
Data last refreshed: (UniProt release unknown)
Key facts
Protein unc-45 homolog A (UNC45A) is a protein from Homo sapiens identified by UniProt accession Q9H3U1, 944 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.
- UniProt accession: Q9H3U1; gene symbol UNC45A.
- Organism: Homo sapiens.
- Length: 944 amino acids.
- Top disease associations (Open Targets): osteootohepatoenteric syndrome, Increased susceptibility to fractures and Diarrhea.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein unc-45 homolog A |
|---|---|
| UniProt accession | Q9H3U1 |
| Gene | UNC45A |
| Organism | Homo sapiens |
| Length | 944 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (128)
Diseases linked to this target (Open Targets).
- osteootohepatoenteric syndrome · score 0.73
- Increased susceptibility to fractures · score 0.41
- Diarrhea · score 0.41
- Cholestasis · score 0.37
- diarrheal disease · score 0.37
- cholestasis · score 0.37
- genetic disorder · score 0.19
- type 2 diabetes mellitus · score 0.17
- mean platelet volume · score 0.15
- systolic blood pressure · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3U1-F1 | alphafold | PREDICTED | 86.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3U1.
Amino-acid sequence (944 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UNC45A?
The strongest Open Targets associations for UNC45A are osteootohepatoenteric syndrome, Increased susceptibility to fractures, Diarrhea, Cholestasis and diarrheal disease.
How long is the UNC45A protein?
The Homo sapiens UNC45A protein (UniProt Q9H3U1) is 944 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3U1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3U1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.