SPARC-related modular calcium-binding protein 2 (SMOC2)
Homo sapiens — UniProt Q9H3U7
Data last refreshed: (UniProt release unknown)
Key facts
SPARC-related modular calcium-binding protein 2 (SMOC2) is a protein from Homo sapiens identified by UniProt accession Q9H3U7, 446 residues long. MolForge cross-references it against 0 known binders and 152 disease associations.
- UniProt accession: Q9H3U7; gene symbol SMOC2.
- Organism: Homo sapiens.
- Length: 446 amino acids.
- Top disease associations (Open Targets): dentin dysplasia type I, body height and BMI-adjusted waist circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SPARC-related modular calcium-binding protein 2 |
|---|---|
| UniProt accession | Q9H3U7 |
| Gene | SMOC2 |
| Organism | Homo sapiens |
| Length | 446 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (152)
Diseases linked to this target (Open Targets).
- dentin dysplasia type I · score 0.56
- body height · score 0.50
- BMI-adjusted waist circumference · score 0.44
- atypical dentin dysplasia due to SMOC2 deficiency · score 0.41
- appendicular lean mass · score 0.40
- alkaline phosphatase measurement · score 0.34
- pulse pressure measurement · score 0.33
- sitting height measurement · score 0.33
- forced expiratory volume · score 0.32
- BMI-adjusted hip circumference · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3U7-F1 | alphafold | PREDICTED | 73.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3U7.
Amino-acid sequence (446 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMOC2?
The strongest Open Targets associations for SMOC2 are dentin dysplasia type I, body height, BMI-adjusted waist circumference, atypical dentin dysplasia due to SMOC2 deficiency and appendicular lean mass.
How long is the SMOC2 protein?
The Homo sapiens SMOC2 protein (UniProt Q9H3U7) is 446 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3U7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3U7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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