Leucine-rich repeat neuronal protein 3 (LRRN3)
Homo sapiens — UniProt Q9H3W5
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat neuronal protein 3 (LRRN3) is a protein from Homo sapiens identified by UniProt accession Q9H3W5, 708 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.
- UniProt accession: Q9H3W5; gene symbol LRRN3.
- Organism: Homo sapiens.
- Length: 708 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, MODY and schizophrenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat neuronal protein 3 |
|---|---|
| UniProt accession | Q9H3W5 |
| Gene | LRRN3 |
| Organism | Homo sapiens |
| Length | 708 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (85)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.26
- MODY · score 0.08
- schizophrenia · score 0.07
- Gorham-Stout disease · score 0.07
- attention deficit hyperactivity disorder · score 0.05
- autism spectrum disorder · score 0.05
- osteoporosis · score 0.05
- Osteoporosis · score 0.05
- diabetes mellitus, transient neonatal, 2 · score 0.05
- melorheostosis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3W5-F1 | alphafold | PREDICTED | 83.15 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3W5.
Amino-acid sequence (708 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRN3?
The strongest Open Targets associations for LRRN3 are neurodegenerative disease, MODY, schizophrenia, Gorham-Stout disease and attention deficit hyperactivity disorder.
How long is the LRRN3 protein?
The Homo sapiens LRRN3 protein (UniProt Q9H3W5) is 708 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3W5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3W5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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