Tyrosine-protein kinase Srms (SRMS)
Homo sapiens — UniProt Q9H3Y6
Data last refreshed: (UniProt release unknown)
Key facts
Tyrosine-protein kinase Srms (SRMS) is a protein from Homo sapiens identified by UniProt accession Q9H3Y6, 488 residues long. MolForge cross-references it against 7 known binders and 122 disease associations.
- UniProt accession: Q9H3Y6; gene symbol SRMS.
- Organism: Homo sapiens.
- Length: 488 amino acids.
- Approved drugs acting on it (DrugCentral): Dasatinib.
- Top disease associations (Open Targets): chronic myelogenous leukemia, acute lymphoblastic leukemia and lymphoid leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tyrosine-protein kinase Srms |
|---|---|
| UniProt accession | Q9H3Y6 |
| Gene | SRMS |
| Organism | Homo sapiens |
| Length | 488 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (122)
Diseases linked to this target (Open Targets).
- chronic myelogenous leukemia · score 0.58
- acute lymphoblastic leukemia · score 0.55
- lymphoid leukemia · score 0.45
- neoplasm · score 0.41
- multiple myeloma · score 0.40
- Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive · score 0.37
- lymphoid neoplasm · score 0.37
- leukemia · score 0.35
- acute myeloid leukemia · score 0.29
- prostate adenocarcinoma · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3Y6-F1 | alphafold | PREDICTED | 83.29 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3Y6.
Amino-acid sequence (488 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target SRMS?
DrugCentral lists 1 approved drug whose mechanism of action is SRMS: Dasatinib.
Which diseases are associated with SRMS?
The strongest Open Targets associations for SRMS are chronic myelogenous leukemia, acute lymphoblastic leukemia, lymphoid leukemia, neoplasm and multiple myeloma.
How long is the SRMS protein?
The Homo sapiens SRMS protein (UniProt Q9H3Y6) is 488 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3Y6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3Y6 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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