DnaJ homolog subfamily C member 5 (DNAJC5)
Homo sapiens — UniProt Q9H3Z4
Data last refreshed: (UniProt release unknown)
Key facts
DnaJ homolog subfamily C member 5 (DNAJC5) is a protein from Homo sapiens identified by UniProt accession Q9H3Z4, 198 residues long. MolForge cross-references it against 0 known binders and 283 disease associations.
- UniProt accession: Q9H3Z4; gene symbol DNAJC5.
- Organism: Homo sapiens.
- Length: 198 amino acids.
- Top disease associations (Open Targets): CLN4B disease, ceroid lipofuscinosis, neuronal, 4 (Kufs type) and adult neuronal ceroid lipofuscinosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DnaJ homolog subfamily C member 5 |
|---|---|
| UniProt accession | Q9H3Z4 |
| Gene | DNAJC5 |
| Organism | Homo sapiens |
| Length | 198 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (283)
Diseases linked to this target (Open Targets).
- CLN4B disease · score 0.78
- ceroid lipofuscinosis, neuronal, 4 (Kufs type) · score 0.76
- adult neuronal ceroid lipofuscinosis · score 0.56
- neuronal ceroid lipofuscinosis · score 0.42
- mean platelet volume · score 0.24
- mean reticulocyte volume · score 0.19
- genetic disorder · score 0.18
- Immature Reticulocyte Fraction Measurement · score 0.14
- reticulocyte measurement · score 0.13
- cutaneous melanoma · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3Z4-F1 | alphafold | PREDICTED | 73.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3Z4.
Amino-acid sequence (198 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNAJC5?
The strongest Open Targets associations for DNAJC5 are CLN4B disease, ceroid lipofuscinosis, neuronal, 4 (Kufs type), adult neuronal ceroid lipofuscinosis, neuronal ceroid lipofuscinosis and mean platelet volume.
How long is the DNAJC5 protein?
The Homo sapiens DNAJC5 protein (UniProt Q9H3Z4) is 198 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3Z4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3Z4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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