Lck-interacting transmembrane adapter 1 (LIME1)
Homo sapiens — UniProt Q9H400
Data last refreshed: (UniProt release unknown)
Key facts
Lck-interacting transmembrane adapter 1 (LIME1) is a protein from Homo sapiens identified by UniProt accession Q9H400, 295 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: Q9H400; gene symbol LIME1.
- Organism: Homo sapiens.
- Length: 295 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, serum alanine aminotransferase measurement and glomerular filtration rate.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Lck-interacting transmembrane adapter 1 |
|---|---|
| UniProt accession | Q9H400 |
| Gene | LIME1 |
| Organism | Homo sapiens |
| Length | 295 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- serum alanine aminotransferase measurement · score 0.20
- glomerular filtration rate · score 0.19
- aspartate aminotransferase measurement · score 0.17
- C-reactive protein measurement · score 0.16
- IGF-1 measurement · score 0.13
- sex hormone-binding globulin measurement · score 0.13
- mean corpuscular volume · score 0.13
- vital capacity · score 0.12
- serum gamma-glutamyl transferase measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H400-F1 | alphafold | PREDICTED | 53.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H400.
Amino-acid sequence (295 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LIME1?
The strongest Open Targets associations for LIME1 are neurodegenerative disease, serum alanine aminotransferase measurement, glomerular filtration rate, aspartate aminotransferase measurement and C-reactive protein measurement.
How long is the LIME1 protein?
The Homo sapiens LIME1 protein (UniProt Q9H400) is 295 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H400 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H400 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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