Homeodomain-interacting protein kinase 3 (HIPK3)
Homo sapiens — UniProt Q9H422
Data last refreshed: (UniProt release unknown)
Key facts
Homeodomain-interacting protein kinase 3 (HIPK3) is a protein from Homo sapiens identified by UniProt accession Q9H422, 1215 residues long. MolForge cross-references it against 10 known binders and 136 disease associations.
- UniProt accession: Q9H422; gene symbol HIPK3.
- Organism: Homo sapiens.
- Length: 1215 amino acids.
- Top disease associations (Open Targets): body height, neuroinflammatory disorder and cholangiocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homeodomain-interacting protein kinase 3 |
|---|---|
| UniProt accession | Q9H422 |
| Gene | HIPK3 |
| Organism | Homo sapiens |
| Length | 1215 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (136)
Diseases linked to this target (Open Targets).
- body height · score 0.25
- neuroinflammatory disorder · score 0.16
- cholangiocarcinoma · score 0.09
- cystatin C measurement · score 0.09
- alcohol consumption measurement · score 0.09
- non-small cell lung carcinoma · score 0.08
- calf circumference measurement · score 0.08
- esophageal squamous cell carcinoma · score 0.07
- neoplasm · score 0.07
- nonpapillary renal cell carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H422-F1 | alphafold | PREDICTED | 51.82 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H422.
Amino-acid sequence (1215 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HIPK3?
The strongest Open Targets associations for HIPK3 are body height, neuroinflammatory disorder, cholangiocarcinoma, cystatin C measurement and alcohol consumption measurement.
How long is the HIPK3 protein?
The Homo sapiens HIPK3 protein (UniProt Q9H422) is 1215 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H422 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H422 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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