Charged multivesicular body protein 4b (CHMP4B)
Homo sapiens — UniProt Q9H444
Data last refreshed: (UniProt release unknown)
Key facts
Charged multivesicular body protein 4b (CHMP4B) is a protein from Homo sapiens identified by UniProt accession Q9H444, 224 residues long. MolForge cross-references it against 0 known binders and 45 disease associations.
- UniProt accession: Q9H444; gene symbol CHMP4B.
- Organism: Homo sapiens.
- Length: 224 amino acids.
- Top disease associations (Open Targets): Posterior polar cataract, neurodegenerative disease and HIV infection.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Charged multivesicular body protein 4b |
|---|---|
| UniProt accession | Q9H444 |
| Gene | CHMP4B |
| Organism | Homo sapiens |
| Length | 224 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (45)
Diseases linked to this target (Open Targets).
- Posterior polar cataract · score 0.68
- neurodegenerative disease · score 0.54
- HIV infection · score 0.46
- viral disease · score 0.46
- early-onset non-syndromic cataract · score 0.46
- severe acute respiratory syndrome · score 0.37
- COVID-19 · score 0.37
- early-onset posterior polar cataract · score 0.37
- type 2 diabetes mellitus · score 0.28
- glucose measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H444-F1 | alphafold | PREDICTED | 78.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H444.
Amino-acid sequence (224 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CHMP4B?
The strongest Open Targets associations for CHMP4B are Posterior polar cataract, neurodegenerative disease, HIV infection, viral disease and early-onset non-syndromic cataract.
How long is the CHMP4B protein?
The Homo sapiens CHMP4B protein (UniProt Q9H444) is 224 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H444 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H444 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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