GPI-anchor transamidase component PIGU (PIGU)
Homo sapiens — UniProt Q9H490
Data last refreshed: (UniProt release unknown)
Key facts
GPI-anchor transamidase component PIGU (PIGU) is a protein from Homo sapiens identified by UniProt accession Q9H490, 435 residues long. MolForge cross-references it against 0 known binders and 67 disease associations.
- UniProt accession: Q9H490; gene symbol PIGU.
- Organism: Homo sapiens.
- Length: 435 amino acids.
- Top disease associations (Open Targets): glycosylphosphatidylinositol biosynthesis defect 21, body height and hair color.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GPI-anchor transamidase component PIGU |
|---|---|
| UniProt accession | Q9H490 |
| Gene | PIGU |
| Organism | Homo sapiens |
| Length | 435 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (67)
Diseases linked to this target (Open Targets).
- glycosylphosphatidylinositol biosynthesis defect 21 · score 0.67
- body height · score 0.25
- hair color · score 0.24
- cutaneous melanoma · score 0.24
- suntan · score 0.19
- genetic disorder · score 0.18
- neutrophil count · score 0.17
- serum alanine aminotransferase measurement · score 0.17
- platelet component distribution width · score 0.16
- high density lipoprotein cholesterol measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H490-F1 | alphafold | PREDICTED | 92.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H490.
Amino-acid sequence (435 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIGU?
The strongest Open Targets associations for PIGU are glycosylphosphatidylinositol biosynthesis defect 21, body height, hair color, cutaneous melanoma and suntan.
How long is the PIGU protein?
The Homo sapiens PIGU protein (UniProt Q9H490) is 435 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H490 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H490 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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