Microtubule-associated protein 1 light chain 3 alpha (MAP1LC3A)
Homo sapiens — UniProt Q9H492
Data last refreshed: (UniProt release unknown)
Key facts
Microtubule-associated protein 1 light chain 3 alpha (MAP1LC3A) is a protein from Homo sapiens identified by UniProt accession Q9H492, 121 residues long. MolForge cross-references it against 1 known binders and 651 disease associations.
- UniProt accession: Q9H492; gene symbol MAP1LC3A.
- Organism: Homo sapiens.
- Length: 121 amino acids.
- Top disease associations (Open Targets): serum alanine aminotransferase measurement, glomerular filtration rate and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Microtubule-associated protein 1 light chain 3 alpha |
|---|---|
| UniProt accession | Q9H492 |
| Gene | MAP1LC3A |
| Organism | Homo sapiens |
| Length | 121 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (651)
Diseases linked to this target (Open Targets).
- serum alanine aminotransferase measurement · score 0.17
- glomerular filtration rate · score 0.12
- hepatocellular carcinoma · score 0.11
- neoplasm · score 0.11
- high density lipoprotein cholesterol measurement · score 0.11
- creatinine measurement · score 0.11
- aspartate aminotransferase measurement · score 0.11
- hair color · score 0.09
- infection · score 0.09
- infect · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H492-F1 | alphafold | PREDICTED | 91.28 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H492.
Amino-acid sequence (121 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAP1LC3A?
The strongest Open Targets associations for MAP1LC3A are serum alanine aminotransferase measurement, glomerular filtration rate, hepatocellular carcinoma, neoplasm and high density lipoprotein cholesterol measurement.
How long is the MAP1LC3A protein?
The Homo sapiens MAP1LC3A protein (UniProt Q9H492) is 121 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H492 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H492 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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