tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (OSGEPL1)
Homo sapiens — UniProt Q9H4B0
Data last refreshed: (UniProt release unknown)
Key facts
tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (OSGEPL1) is a protein from Homo sapiens identified by UniProt accession Q9H4B0, 414 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: Q9H4B0; gene symbol OSGEPL1.
- Organism: Homo sapiens.
- Length: 414 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, ferritin measurement and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial |
|---|---|
| UniProt accession | Q9H4B0 |
| Gene | OSGEPL1 |
| Organism | Homo sapiens |
| Length | 414 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.33
- ferritin measurement · score 0.16
- Red cell distribution width · score 0.05
- multiple myeloma · score 0.01
- colorectal cancer · score 0.01
- cancer · score 0.01
- triple-negative breast cancer · score 0.01
- MERRF · score 0.00
- major depressive disorder · score 0.00
- schizophrenia · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4B0-F1 | alphafold | PREDICTED | 91.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4B0.
Amino-acid sequence (414 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with OSGEPL1?
The strongest Open Targets associations for OSGEPL1 are neurodegenerative disease, ferritin measurement, Red cell distribution width, multiple myeloma and colorectal cancer.
How long is the OSGEPL1 protein?
The Homo sapiens OSGEPL1 protein (UniProt Q9H4B0) is 414 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4B0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4B0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.