Serine/threonine-protein kinase PLK3 (PLK3)
Homo sapiens — UniProt Q9H4B4
Data last refreshed: (UniProt release unknown)
Key facts
Serine/threonine-protein kinase PLK3 (PLK3) is a protein from Homo sapiens identified by UniProt accession Q9H4B4, 646 residues long. MolForge cross-references it against 3 known binders and 151 disease associations.
- UniProt accession: Q9H4B4; gene symbol PLK3.
- Organism: Homo sapiens.
- Length: 646 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, multiple sclerosis and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Serine/threonine-protein kinase PLK3 |
|---|---|
| UniProt accession | Q9H4B4 |
| Gene | PLK3 |
| Organism | Homo sapiens |
| Length | 646 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (151)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.27
- multiple sclerosis · score 0.27
- Alzheimer disease · score 0.27
- lysosomal storage disease · score 0.27
- neurodegenerative disease · score 0.27
- Parkinson disease · score 0.27
- breast adenocarcinoma · score 0.26
- lung adenocarcinoma · score 0.25
- head and neck squamous cell carcinoma · score 0.25
- endometrial cancer · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4B4-F1 | alphafold | PREDICTED | 79.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4B4.
Amino-acid sequence (646 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLK3?
The strongest Open Targets associations for PLK3 are glioblastoma multiforme, multiple sclerosis, Alzheimer disease, lysosomal storage disease and neurodegenerative disease.
How long is the PLK3 protein?
The Homo sapiens PLK3 protein (UniProt Q9H4B4) is 646 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4B4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4B4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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