Protein salvador homolog 1 (SAV1)
Homo sapiens — UniProt Q9H4B6
Data last refreshed: (UniProt release unknown)
Key facts
Protein salvador homolog 1 (SAV1) is a protein from Homo sapiens identified by UniProt accession Q9H4B6, 383 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.
- UniProt accession: Q9H4B6; gene symbol SAV1.
- Organism: Homo sapiens.
- Length: 383 amino acids.
- Top disease associations (Open Targets): platelet count, mean platelet volume and platelet component distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein salvador homolog 1 |
|---|---|
| UniProt accession | Q9H4B6 |
| Gene | SAV1 |
| Organism | Homo sapiens |
| Length | 383 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (181)
Diseases linked to this target (Open Targets).
- platelet count · score 0.36
- mean platelet volume · score 0.36
- platelet component distribution width · score 0.24
- sitting height measurement · score 0.23
- Autosomal dominant spastic paraplegia type 3 · score 0.19
- hereditary spastic paraplegia 3A · score 0.19
- genetic disorder · score 0.17
- body height · score 0.16
- serum albumin measurement · score 0.15
- coronary artery disease · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4B6-F1 | alphafold | PREDICTED | 59.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4B6.
Amino-acid sequence (383 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SAV1?
The strongest Open Targets associations for SAV1 are platelet count, mean platelet volume, platelet component distribution width, sitting height measurement and Autosomal dominant spastic paraplegia type 3.
How long is the SAV1 protein?
The Homo sapiens SAV1 protein (UniProt Q9H4B6) is 383 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4B6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4B6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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