Tubulin beta-1 chain (TUBB1)
Homo sapiens — UniProt Q9H4B7
Data last refreshed: (UniProt release unknown)
Key facts
Tubulin beta-1 chain (TUBB1) is a protein from Homo sapiens identified by UniProt accession Q9H4B7, 451 residues long. MolForge cross-references it against 0 known binders and 575 disease associations.
- UniProt accession: Q9H4B7; gene symbol TUBB1.
- Organism: Homo sapiens.
- Length: 451 amino acids.
- Top disease associations (Open Targets): mean platelet volume, platelet component distribution width and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tubulin beta-1 chain |
|---|---|
| UniProt accession | Q9H4B7 |
| Gene | TUBB1 |
| Organism | Homo sapiens |
| Length | 451 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (575)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.71
- platelet component distribution width · score 0.70
- platelet count · score 0.70
- platelet crit · score 0.69
- autosomal dominant macrothrombocytopenia · score 0.67
- head and neck squamous cell carcinoma · score 0.61
- breast cancer · score 0.61
- non-small cell lung carcinoma · score 0.61
- breast carcinoma · score 0.60
- ovarian cancer · score 0.60
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4B7-F1 | alphafold | PREDICTED | 90.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4B7.
Amino-acid sequence (451 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TUBB1?
The strongest Open Targets associations for TUBB1 are mean platelet volume, platelet component distribution width, platelet count, platelet crit and autosomal dominant macrothrombocytopenia.
How long is the TUBB1 protein?
The Homo sapiens TUBB1 protein (UniProt Q9H4B7) is 451 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4B7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4B7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.