Dipeptidase 3 (DPEP3)
Homo sapiens — UniProt Q9H4B8
Data last refreshed: (UniProt release unknown)
Key facts
Dipeptidase 3 (DPEP3) is a protein from Homo sapiens identified by UniProt accession Q9H4B8, 488 residues long. MolForge cross-references it against 0 known binders and 92 disease associations.
- UniProt accession: Q9H4B8; gene symbol DPEP3.
- Organism: Homo sapiens.
- Length: 488 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, high density lipoprotein cholesterol measurement and alcohol drinking.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dipeptidase 3 |
|---|---|
| UniProt accession | Q9H4B8 |
| Gene | DPEP3 |
| Organism | Homo sapiens |
| Length | 488 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (92)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- high density lipoprotein cholesterol measurement · score 0.22
- alcohol drinking · score 0.16
- lysosomal storage disease · score 0.15
- alcohol consumption measurement · score 0.14
- glioblastoma multiforme · score 0.13
- cutaneous melanoma · score 0.13
- head and neck squamous cell carcinoma · score 0.11
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4B8-F1 | alphafold | PREDICTED | 83.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4B8.
Amino-acid sequence (488 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DPEP3?
The strongest Open Targets associations for DPEP3 are neurodegenerative disease, high density lipoprotein cholesterol measurement, alcohol drinking, lysosomal storage disease and alcohol consumption measurement.
How long is the DPEP3 protein?
The Homo sapiens DPEP3 protein (UniProt Q9H4B8) is 488 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4B8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4B8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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