Calsyntenin-2 (CLSTN2)
Homo sapiens — UniProt Q9H4D0
Data last refreshed: (UniProt release unknown)
Key facts
Calsyntenin-2 (CLSTN2) is a protein from Homo sapiens identified by UniProt accession Q9H4D0, 955 residues long. MolForge cross-references it against 0 known binders and 59 disease associations.
- UniProt accession: Q9H4D0; gene symbol CLSTN2.
- Organism: Homo sapiens.
- Length: 955 amino acids.
- Top disease associations (Open Targets): PHF-tau measurement, self reported educational attainment and cognitive function measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calsyntenin-2 |
|---|---|
| UniProt accession | Q9H4D0 |
| Gene | CLSTN2 |
| Organism | Homo sapiens |
| Length | 955 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (59)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.40
- self reported educational attainment · score 0.39
- cognitive function measurement · score 0.37
- protein measurement · score 0.34
- neurofibrillary tangles measurement · score 0.32
- intelligence · score 0.27
- age at first sexual intercourse measurement · score 0.27
- blood protein measurement · score 0.26
- age-related hearing impairment · score 0.15
- attention deficit hyperactivity disorder · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4D0-F1 | alphafold | PREDICTED | 78.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4D0.
Amino-acid sequence (955 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CLSTN2?
The strongest Open Targets associations for CLSTN2 are PHF-tau measurement, self reported educational attainment, cognitive function measurement, protein measurement and neurofibrillary tangles measurement.
How long is the CLSTN2 protein?
The Homo sapiens CLSTN2 protein (UniProt Q9H4D0) is 955 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4D0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4D0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.