Nuclear RNA export factor 3 (NXF3)
Homo sapiens — UniProt Q9H4D5
Data last refreshed: (UniProt release unknown)
Key facts
Nuclear RNA export factor 3 (NXF3) is a protein from Homo sapiens identified by UniProt accession Q9H4D5, 531 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q9H4D5; gene symbol NXF3.
- Organism: Homo sapiens.
- Length: 531 amino acids.
- Top disease associations (Open Targets): hepatocellular carcinoma, Barrett's esophagus and Crohn's disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nuclear RNA export factor 3 |
|---|---|
| UniProt accession | Q9H4D5 |
| Gene | NXF3 |
| Organism | Homo sapiens |
| Length | 531 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- hepatocellular carcinoma · score 0.08
- Barrett's esophagus · score 0.04
- Crohn's disease · score 0.03
- Colon Sessile Serrated Adenoma/Polyp · score 0.03
- sessile serrated polyp · score 0.03
- neoplasm · score 0.02
- lung carcinoma · score 0.02
- non-small cell lung carcinoma · score 0.01
- cancer · score 0.01
- lung adenocarcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4D5-F1 | alphafold | PREDICTED | 62.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4D5.
Amino-acid sequence (531 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NXF3?
The strongest Open Targets associations for NXF3 are hepatocellular carcinoma, Barrett's esophagus, Crohn's disease, Colon Sessile Serrated Adenoma/Polyp and sessile serrated polyp.
How long is the NXF3 protein?
The Homo sapiens NXF3 protein (UniProt Q9H4D5) is 531 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4D5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4D5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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