Rho-related GTP-binding protein RhoJ (RHOJ)
Homo sapiens — UniProt Q9H4E5
Data last refreshed: (UniProt release unknown)
Key facts
Rho-related GTP-binding protein RhoJ (RHOJ) is a protein from Homo sapiens identified by UniProt accession Q9H4E5, 214 residues long. MolForge cross-references it against 0 known binders and 81 disease associations.
- UniProt accession: Q9H4E5; gene symbol RHOJ.
- Organism: Homo sapiens.
- Length: 214 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, bone quantitative ultrasound measurement and rosacea.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho-related GTP-binding protein RhoJ |
|---|---|
| UniProt accession | Q9H4E5 |
| Gene | RHOJ |
| Organism | Homo sapiens |
| Length | 214 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (81)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.42
- bone quantitative ultrasound measurement · score 0.31
- rosacea · score 0.25
- ptosis · score 0.17
- neoplasm · score 0.10
- gonorrhea · score 0.09
- glioblastoma multiforme · score 0.08
- melanoma · score 0.08
- age-related macular degeneration · score 0.08
- X-linked retinal dysplasia · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4E5-F1 | alphafold | PREDICTED | 88.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4E5.
Amino-acid sequence (214 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RHOJ?
The strongest Open Targets associations for RHOJ are heel bone mineral density, bone quantitative ultrasound measurement, rosacea, ptosis and neoplasm.
How long is the RHOJ protein?
The Homo sapiens RHOJ protein (UniProt Q9H4E5) is 214 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4E5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4E5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.