Differentially expressed in FDCP 6 homolog (DEF6)
Homo sapiens — UniProt Q9H4E7
Data last refreshed: (UniProt release unknown)
Key facts
Differentially expressed in FDCP 6 homolog (DEF6) is a protein from Homo sapiens identified by UniProt accession Q9H4E7, 631 residues long. MolForge cross-references it against 0 known binders and 184 disease associations.
- UniProt accession: Q9H4E7; gene symbol DEF6.
- Organism: Homo sapiens.
- Length: 631 amino acids.
- Top disease associations (Open Targets): immunodeficiency 87 and autoimmunity, bilirubin measurement and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Differentially expressed in FDCP 6 homolog |
|---|---|
| UniProt accession | Q9H4E7 |
| Gene | DEF6 |
| Organism | Homo sapiens |
| Length | 631 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (184)
Diseases linked to this target (Open Targets).
- immunodeficiency 87 and autoimmunity · score 0.64
- bilirubin measurement · score 0.34
- leukocyte count · score 0.26
- serum alanine aminotransferase measurement · score 0.23
- myeloid white cell count · score 0.23
- asthma · score 0.22
- body height · score 0.20
- neutrophil count · score 0.20
- lymphocyte count · score 0.20
- apolipoprotein A 1 measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4E7-F1 | alphafold | PREDICTED | 78.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4E7.
Amino-acid sequence (631 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DEF6?
The strongest Open Targets associations for DEF6 are immunodeficiency 87 and autoimmunity, bilirubin measurement, leukocyte count, serum alanine aminotransferase measurement and myeloid white cell count.
How long is the DEF6 protein?
The Homo sapiens DEF6 protein (UniProt Q9H4E7) is 631 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4E7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4E7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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