Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase (ST6GALNAC4)
Homo sapiens — UniProt Q9H4F1
Data last refreshed: (UniProt release unknown)
Key facts
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase (ST6GALNAC4) is a protein from Homo sapiens identified by UniProt accession Q9H4F1, 302 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.
- UniProt accession: Q9H4F1; gene symbol ST6GALNAC4.
- Organism: Homo sapiens.
- Length: 302 amino acids.
- Top disease associations (Open Targets): COVID-19, severe acute respiratory syndrome and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase |
|---|---|
| UniProt accession | Q9H4F1 |
| Gene | ST6GALNAC4 |
| Organism | Homo sapiens |
| Length | 302 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (83)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.46
- severe acute respiratory syndrome · score 0.37
- glioblastoma multiforme · score 0.19
- lung adenocarcinoma · score 0.18
- squamous cell lung carcinoma · score 0.16
- monocyte count · score 0.13
- endometrial cancer · score 0.10
- breast adenocarcinoma · score 0.10
- P-selectin glycoprotein ligand 1 measurement · score 0.10
- gastric adenocarcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4F1-F1 | alphafold | PREDICTED | 89.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4F1.
Amino-acid sequence (302 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ST6GALNAC4?
The strongest Open Targets associations for ST6GALNAC4 are COVID-19, severe acute respiratory syndrome, glioblastoma multiforme, lung adenocarcinoma and squamous cell lung carcinoma.
How long is the ST6GALNAC4 protein?
The Homo sapiens ST6GALNAC4 protein (UniProt Q9H4F1) is 302 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4F1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4F1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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