SPARC-related modular calcium-binding protein 1 (SMOC1)
Homo sapiens — UniProt Q9H4F8
Data last refreshed: (UniProt release unknown)
Key facts
SPARC-related modular calcium-binding protein 1 (SMOC1) is a protein from Homo sapiens identified by UniProt accession Q9H4F8, 434 residues long. MolForge cross-references it against 0 known binders and 550 disease associations.
- UniProt accession: Q9H4F8; gene symbol SMOC1.
- Organism: Homo sapiens.
- Length: 434 amino acids.
- Top disease associations (Open Targets): microphthalmia with limb anomalies, lean body mass and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SPARC-related modular calcium-binding protein 1 |
|---|---|
| UniProt accession | Q9H4F8 |
| Gene | SMOC1 |
| Organism | Homo sapiens |
| Length | 434 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (550)
Diseases linked to this target (Open Targets).
- microphthalmia with limb anomalies · score 0.80
- lean body mass · score 0.47
- Red cell distribution width · score 0.47
- blood protein measurement · score 0.47
- mean corpuscular volume · score 0.47
- Polydactyly · score 0.46
- polydactyly · score 0.46
- appendicular lean mass · score 0.45
- mean corpuscular hemoglobin · score 0.44
- mean corpuscular hemoglobin concentration · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4F8-F1 | alphafold | PREDICTED | 73.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4F8.
Amino-acid sequence (434 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMOC1?
The strongest Open Targets associations for SMOC1 are microphthalmia with limb anomalies, lean body mass, Red cell distribution width, blood protein measurement and mean corpuscular volume.
How long is the SMOC1 protein?
The Homo sapiens SMOC1 protein (UniProt Q9H4F8) is 434 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4F8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4F8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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