Double-strand-break repair protein rad21-like protein 1 (RAD21L1)
Homo sapiens — UniProt Q9H4I0
Data last refreshed: (UniProt release unknown)
Key facts
Double-strand-break repair protein rad21-like protein 1 (RAD21L1) is a protein from Homo sapiens identified by UniProt accession Q9H4I0, 556 residues long. MolForge cross-references it against 0 known binders and 137 disease associations.
- UniProt accession: Q9H4I0; gene symbol RAD21L1.
- Organism: Homo sapiens.
- Length: 556 amino acids.
- Top disease associations (Open Targets): azoospermia, partial chromosome Y deletion and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Double-strand-break repair protein rad21-like protein 1 |
|---|---|
| UniProt accession | Q9H4I0 |
| Gene | RAD21L1 |
| Organism | Homo sapiens |
| Length | 556 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (137)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.36
- partial chromosome Y deletion · score 0.08
- blood protein measurement · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- spermatogenic failures 50 · score 0.07
- spermatogenic failure 25 · score 0.07
- spermatogenic failure 59 · score 0.07
- spermatogenic failure 73 · score 0.07
- spermatogenic failure 74 · score 0.07
- spermatogenic failure, X-linked, 2 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4I0-F1 | alphafold | PREDICTED | 61.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4I0.
Amino-acid sequence (556 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RAD21L1?
The strongest Open Targets associations for RAD21L1 are azoospermia, partial chromosome Y deletion, blood protein measurement, male infertility with teratozoospermia due to single gene mutation and spermatogenic failures 50.
How long is the RAD21L1 protein?
The Homo sapiens RAD21L1 protein (UniProt Q9H4I0) is 556 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4I0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4I0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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