Essential MCU regulator, mitochondrial (SMDT1)
Homo sapiens — UniProt Q9H4I9
Data last refreshed: (UniProt release unknown)
Key facts
Essential MCU regulator, mitochondrial (SMDT1) is a protein from Homo sapiens identified by UniProt accession Q9H4I9, 107 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.
- UniProt accession: Q9H4I9; gene symbol SMDT1.
- Organism: Homo sapiens.
- Length: 107 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, leukocyte count and platelet component distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Essential MCU regulator, mitochondrial |
|---|---|
| UniProt accession | Q9H4I9 |
| Gene | SMDT1 |
| Organism | Homo sapiens |
| Length | 107 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (133)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.25
- leukocyte count · score 0.16
- platelet component distribution width · score 0.11
- schizophrenia · score 0.09
- calcium measurement · score 0.09
- Young adult-onset Parkinsonism · score 0.08
- mean corpuscular volume · score 0.08
- essential tremor · score 0.08
- Hereditary late-onset Parkinson disease · score 0.08
- autism spectrum disorder · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4I9-F1 | alphafold | PREDICTED | 72.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4I9.
Amino-acid sequence (107 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMDT1?
The strongest Open Targets associations for SMDT1 are neurodegenerative disease, leukocyte count, platelet component distribution width, schizophrenia and calcium measurement.
How long is the SMDT1 protein?
The Homo sapiens SMDT1 protein (UniProt Q9H4I9) is 107 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4I9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4I9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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