Mitochondrial ribosome-associated GTPase 2 (MTG2)
Homo sapiens — UniProt Q9H4K7
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial ribosome-associated GTPase 2 (MTG2) is a protein from Homo sapiens identified by UniProt accession Q9H4K7, 406 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q9H4K7; gene symbol MTG2.
- Organism: Homo sapiens.
- Length: 406 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, bone density and urate measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial ribosome-associated GTPase 2 |
|---|---|
| UniProt accession | Q9H4K7 |
| Gene | MTG2 |
| Organism | Homo sapiens |
| Length | 406 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.21
- bone density · score 0.14
- urate measurement · score 0.14
- age-related macular degeneration · score 0.08
- X-linked retinal dysplasia · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.05
- age related macular degeneration 4 · score 0.05
- age related macular degeneration 7 · score 0.05
- age related macular degeneration 11 · score 0.05
- Familial exudative vitreoretinopathy · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4K7-F1 | alphafold | PREDICTED | 75.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4K7.
Amino-acid sequence (406 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MTG2?
The strongest Open Targets associations for MTG2 are neurodegenerative disease, bone density, urate measurement, age-related macular degeneration and X-linked retinal dysplasia.
How long is the MTG2 protein?
The Homo sapiens MTG2 protein (UniProt Q9H4K7) is 406 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4K7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4K7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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