Sentrin-specific protease 3 (SENP3)
Homo sapiens — UniProt Q9H4L4
Data last refreshed: (UniProt release unknown)
Key facts
Sentrin-specific protease 3 (SENP3) is a protein from Homo sapiens identified by UniProt accession Q9H4L4, 574 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.
- UniProt accession: Q9H4L4; gene symbol SENP3.
- Organism: Homo sapiens.
- Length: 574 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, sex hormone-binding globulin measurement and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sentrin-specific protease 3 |
|---|---|
| UniProt accession | Q9H4L4 |
| Gene | SENP3 |
| Organism | Homo sapiens |
| Length | 574 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (133)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- sex hormone-binding globulin measurement · score 0.24
- Red cell distribution width · score 0.12
- myoepithelial tumor · score 0.11
- neoplasm · score 0.10
- testosterone measurement · score 0.10
- hepatocellular carcinoma · score 0.10
- triple-negative breast cancer · score 0.09
- mean corpuscular hemoglobin concentration · score 0.08
- platelet component distribution width · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4L4-F1 | alphafold | PREDICTED | 64.59 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4L4.
Amino-acid sequence (574 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SENP3?
The strongest Open Targets associations for SENP3 are neurodegenerative disease, sex hormone-binding globulin measurement, Red cell distribution width, myoepithelial tumor and neoplasm.
How long is the SENP3 protein?
The Homo sapiens SENP3 protein (UniProt Q9H4L4) is 574 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4L4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4L4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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