SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1)
Homo sapiens — UniProt Q9H4L7
Data last refreshed: (UniProt release unknown)
Key facts
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) is a protein from Homo sapiens identified by UniProt accession Q9H4L7, 1026 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.
- UniProt accession: Q9H4L7; gene symbol SMARCAD1.
- Organism: Homo sapiens.
- Length: 1026 amino acids.
- Top disease associations (Open Targets): palmoplantar keratoderma-sclerodactyly syndrome, Absence of fingerprints - congenital milia and Adermatoglyphia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 |
|---|---|
| UniProt accession | Q9H4L7 |
| Gene | SMARCAD1 |
| Organism | Homo sapiens |
| Length | 1026 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (82)
Diseases linked to this target (Open Targets).
- palmoplantar keratoderma-sclerodactyly syndrome · score 0.59
- Absence of fingerprints - congenital milia · score 0.55
- Adermatoglyphia · score 0.50
- absence of fingerprints-congenital milia syndrome · score 0.47
- isolated congenital adermatoglyphia · score 0.46
- heel bone mineral density · score 0.42
- neurodegenerative disease · score 0.37
- Isolated adermatoglyphia · score 0.37
- type 2 diabetes mellitus · score 0.36
- age at menarche · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4L7-F1 | alphafold | PREDICTED | 67.09 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4L7.
Amino-acid sequence (1026 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMARCAD1?
The strongest Open Targets associations for SMARCAD1 are palmoplantar keratoderma-sclerodactyly syndrome, Absence of fingerprints - congenital milia, Adermatoglyphia, absence of fingerprints-congenital milia syndrome and isolated congenital adermatoglyphia.
How long is the SMARCAD1 protein?
The Homo sapiens SMARCAD1 protein (UniProt Q9H4L7) is 1026 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4L7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4L7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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