Pleckstrin homology domain-containing family A member 4 (PLEKHA4)
Homo sapiens — UniProt Q9H4M7
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology domain-containing family A member 4 (PLEKHA4) is a protein from Homo sapiens identified by UniProt accession Q9H4M7, 779 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.
- UniProt accession: Q9H4M7; gene symbol PLEKHA4.
- Organism: Homo sapiens.
- Length: 779 amino acids.
- Top disease associations (Open Targets): reticulocyte count, reticulocyte measurement and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology domain-containing family A member 4 |
|---|---|
| UniProt accession | Q9H4M7 |
| Gene | PLEKHA4 |
| Organism | Homo sapiens |
| Length | 779 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (55)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.35
- reticulocyte measurement · score 0.28
- Red cell distribution width · score 0.28
- glioblastoma multiforme · score 0.27
- Immature Reticulocyte Fraction Measurement · score 0.26
- breast adenocarcinoma · score 0.25
- head and neck squamous cell carcinoma · score 0.19
- mean corpuscular volume · score 0.15
- blood protein measurement · score 0.11
- prostate carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4M7-F1 | alphafold | PREDICTED | 57.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4M7.
Amino-acid sequence (779 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEKHA4?
The strongest Open Targets associations for PLEKHA4 are reticulocyte count, reticulocyte measurement, Red cell distribution width, glioblastoma multiforme and Immature Reticulocyte Fraction Measurement.
How long is the PLEKHA4 protein?
The Homo sapiens PLEKHA4 protein (UniProt Q9H4M7) is 779 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4M7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4M7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.