E3 ubiquitin-protein ligase NRDP1 (RNF41)
Homo sapiens — UniProt Q9H4P4
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase NRDP1 (RNF41) is a protein from Homo sapiens identified by UniProt accession Q9H4P4, 317 residues long. MolForge cross-references it against 0 known binders and 131 disease associations.
- UniProt accession: Q9H4P4; gene symbol RNF41.
- Organism: Homo sapiens.
- Length: 317 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, breast adenocarcinoma and endometrial cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase NRDP1 |
|---|---|
| UniProt accession | Q9H4P4 |
| Gene | RNF41 |
| Organism | Homo sapiens |
| Length | 317 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (131)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- breast adenocarcinoma · score 0.22
- endometrial cancer · score 0.18
- head and neck squamous cell carcinoma · score 0.13
- azoospermia · score 0.09
- hepatocellular carcinoma · score 0.09
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.08
- connective tissue disease · score 0.08
- musculoskeletal system disease · score 0.08
- glioblastoma multiforme · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4P4-F1 | alphafold | PREDICTED | 92.05 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4P4.
Amino-acid sequence (317 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF41?
The strongest Open Targets associations for RNF41 are neurodegenerative disease, breast adenocarcinoma, endometrial cancer, head and neck squamous cell carcinoma and azoospermia.
How long is the RNF41 protein?
The Homo sapiens RNF41 protein (UniProt Q9H4P4) is 317 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4P4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4P4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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