PR domain zinc finger protein 12 (PRDM12)
Homo sapiens — UniProt Q9H4Q4
Data last refreshed: (UniProt release unknown)
Key facts
PR domain zinc finger protein 12 (PRDM12) is a protein from Homo sapiens identified by UniProt accession Q9H4Q4, 367 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.
- UniProt accession: Q9H4Q4; gene symbol PRDM12.
- Organism: Homo sapiens.
- Length: 367 amino acids.
- Top disease associations (Open Targets): congenital insensitivity to pain-hypohidrosis syndrome, genetic disorder and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | PR domain zinc finger protein 12 |
|---|---|
| UniProt accession | Q9H4Q4 |
| Gene | PRDM12 |
| Organism | Homo sapiens |
| Length | 367 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (79)
Diseases linked to this target (Open Targets).
- congenital insensitivity to pain-hypohidrosis syndrome · score 0.81
- genetic disorder · score 0.41
- neurodegenerative disease · score 0.27
- Red cell distribution width · score 0.11
- body height · score 0.09
- Romano-Ward syndrome · score 0.06
- Arrhythmogenic right ventricular dysplasia · score 0.05
- hemoglobin measurement · score 0.05
- Familial short QT syndrome · score 0.05
- Brugada syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4Q4-F1 | alphafold | PREDICTED | 63.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4Q4.
Amino-acid sequence (367 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRDM12?
The strongest Open Targets associations for PRDM12 are congenital insensitivity to pain-hypohidrosis syndrome, genetic disorder, neurodegenerative disease, Red cell distribution width and body height.
How long is the PRDM12 protein?
The Homo sapiens PRDM12 protein (UniProt Q9H4Q4) is 367 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4Q4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4Q4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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