GS homeobox 1 (GSX1)
Homo sapiens — UniProt Q9H4S2
Data last refreshed: (UniProt release unknown)
Key facts
GS homeobox 1 (GSX1) is a protein from Homo sapiens identified by UniProt accession Q9H4S2, 264 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q9H4S2; gene symbol GSX1.
- Organism: Homo sapiens.
- Length: 264 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body height and IGF-1 measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GS homeobox 1 |
|---|---|
| UniProt accession | Q9H4S2 |
| Gene | GSX1 |
| Organism | Homo sapiens |
| Length | 264 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- body height · score 0.30
- IGF-1 measurement · score 0.23
- insulin like growth factor measurement · score 0.23
- DNA methylation · score 0.19
- serum alanine aminotransferase measurement · score 0.15
- lean body mass · score 0.15
- fat body mass · score 0.15
- serum gamma-glutamyl transferase measurement · score 0.15
- aspartate aminotransferase measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4S2-F1 | alphafold | PREDICTED | 63.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4S2.
Amino-acid sequence (264 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GSX1?
The strongest Open Targets associations for GSX1 are neurodegenerative disease, body height, IGF-1 measurement, insulin like growth factor measurement and DNA methylation.
How long is the GSX1 protein?
The Homo sapiens GSX1 protein (UniProt Q9H4S2) is 264 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4S2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4S2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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