Transcription factor COE3 (EBF3)
Homo sapiens — UniProt Q9H4W6
Data last refreshed: (UniProt release unknown)
Key facts
Transcription factor COE3 (EBF3) is a protein from Homo sapiens identified by UniProt accession Q9H4W6, 596 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.
- UniProt accession: Q9H4W6; gene symbol EBF3.
- Organism: Homo sapiens.
- Length: 596 amino acids.
- Top disease associations (Open Targets): Leukoencephalopathy - ataxia - hypodontia - hypomyelination, genetic disorder and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transcription factor COE3 |
|---|---|
| UniProt accession | Q9H4W6 |
| Gene | EBF3 |
| Organism | Homo sapiens |
| Length | 596 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (85)
Diseases linked to this target (Open Targets).
- Leukoencephalopathy - ataxia - hypodontia - hypomyelination · score 0.76
- genetic disorder · score 0.54
- neurodegenerative disease · score 0.48
- Hypotonia · score 0.46
- Global developmental delay · score 0.46
- Intellectual disability · score 0.46
- Ataxia · score 0.43
- Expressive language delay · score 0.43
- Generalized hypotonia · score 0.42
- autism spectrum disorder · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4W6-F1 | alphafold | PREDICTED | 70.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4W6.
Amino-acid sequence (596 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EBF3?
The strongest Open Targets associations for EBF3 are Leukoencephalopathy - ataxia - hypodontia - hypomyelination, genetic disorder, neurodegenerative disease, Hypotonia and Global developmental delay.
How long is the EBF3 protein?
The Homo sapiens EBF3 protein (UniProt Q9H4W6) is 596 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4W6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4W6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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