Zinc finger protein 335 (ZNF335)
Homo sapiens — UniProt Q9H4Z2
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 335 (ZNF335) is a protein from Homo sapiens identified by UniProt accession Q9H4Z2, 1342 residues long. MolForge cross-references it against 0 known binders and 139 disease associations.
- UniProt accession: Q9H4Z2; gene symbol ZNF335.
- Organism: Homo sapiens.
- Length: 1342 amino acids.
- Top disease associations (Open Targets): microcephalic primordial dwarfism due to ZNF335 deficiency, autosomal recessive primary microcephaly and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 335 |
|---|---|
| UniProt accession | Q9H4Z2 |
| Gene | ZNF335 |
| Organism | Homo sapiens |
| Length | 1342 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (139)
Diseases linked to this target (Open Targets).
- microcephalic primordial dwarfism due to ZNF335 deficiency · score 0.74
- autosomal recessive primary microcephaly · score 0.54
- neurodegenerative disease · score 0.51
- genetic disorder · score 0.49
- Neurological conditions associated with aminoacylase 1 deficiency · score 0.26
- endometrial cancer · score 0.23
- high density lipoprotein cholesterol measurement · score 0.23
- breast adenocarcinoma · score 0.22
- coronary artery disease · score 0.22
- celiac disease · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4Z2-F1 | alphafold | PREDICTED | 51.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4Z2.
Amino-acid sequence (1342 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF335?
The strongest Open Targets associations for ZNF335 are microcephalic primordial dwarfism due to ZNF335 deficiency, autosomal recessive primary microcephaly, neurodegenerative disease, genetic disorder and Neurological conditions associated with aminoacylase 1 deficiency.
How long is the ZNF335 protein?
The Homo sapiens ZNF335 protein (UniProt Q9H4Z2) is 1342 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4Z2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4Z2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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