mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (PCIF1)
Homo sapiens — UniProt Q9H4Z3
Data last refreshed: (UniProt release unknown)
Key facts
mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (PCIF1) is a protein from Homo sapiens identified by UniProt accession Q9H4Z3, 704 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.
- UniProt accession: Q9H4Z3; gene symbol PCIF1.
- Organism: Homo sapiens.
- Length: 704 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, triglyceride measurement and erythrocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase |
|---|---|
| UniProt accession | Q9H4Z3 |
| Gene | PCIF1 |
| Organism | Homo sapiens |
| Length | 704 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (87)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.30
- triglyceride measurement · score 0.18
- erythrocyte count · score 0.17
- mean corpuscular hemoglobin concentration · score 0.16
- mean reticulocyte volume · score 0.15
- Red cell distribution width · score 0.15
- high density lipoprotein cholesterol measurement · score 0.15
- mean corpuscular volume · score 0.14
- mean corpuscular hemoglobin · score 0.14
- C-reactive protein measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H4Z3-F1 | alphafold | PREDICTED | 80.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H4Z3.
Amino-acid sequence (704 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PCIF1?
The strongest Open Targets associations for PCIF1 are neurodegenerative disease, triglyceride measurement, erythrocyte count, mean corpuscular hemoglobin concentration and mean reticulocyte volume.
How long is the PCIF1 protein?
The Homo sapiens PCIF1 protein (UniProt Q9H4Z3) is 704 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H4Z3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H4Z3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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