Alpha-1,3/1,6-mannosyltransferase ALG2 (ALG2)
Homo sapiens — UniProt Q9H553
Data last refreshed: (UniProt release unknown)
Key facts
Alpha-1,3/1,6-mannosyltransferase ALG2 (ALG2) is a protein from Homo sapiens identified by UniProt accession Q9H553, 416 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q9H553; gene symbol ALG2.
- Organism: Homo sapiens.
- Length: 416 amino acids.
- Top disease associations (Open Targets): ALG2-congenital disorder of glycosylation, Congenital myasthenic syndromes and congenital disorder of glycosylation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alpha-1,3/1,6-mannosyltransferase ALG2 |
|---|---|
| UniProt accession | Q9H553 |
| Gene | ALG2 |
| Organism | Homo sapiens |
| Length | 416 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- ALG2-congenital disorder of glycosylation · score 0.72
- Congenital myasthenic syndromes · score 0.67
- congenital disorder of glycosylation · score 0.51
- neurodegenerative disease · score 0.45
- congenital disorder of glycosylation type I · score 0.37
- congenital myasthenic syndromes with glycosylation defect · score 0.37
- mathematical ability · score 0.23
- genetic disorder · score 0.19
- smoking status measurement · score 0.18
- cognitive function measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H553-F1 | alphafold | PREDICTED | 91.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H553.
Amino-acid sequence (416 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ALG2?
The strongest Open Targets associations for ALG2 are ALG2-congenital disorder of glycosylation, Congenital myasthenic syndromes, congenital disorder of glycosylation, neurodegenerative disease and congenital disorder of glycosylation type I.
How long is the ALG2 protein?
The Homo sapiens ALG2 protein (UniProt Q9H553) is 416 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H553 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H553 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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