Actin-like protein 8 (ACTL8)
Homo sapiens — UniProt Q9H568
Data last refreshed: (UniProt release unknown)
Key facts
Actin-like protein 8 (ACTL8) is a protein from Homo sapiens identified by UniProt accession Q9H568, 366 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q9H568; gene symbol ACTL8.
- Organism: Homo sapiens.
- Length: 366 amino acids.
- Top disease associations (Open Targets): protein measurement, major depressive disorder and neuroticism measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Actin-like protein 8 |
|---|---|
| UniProt accession | Q9H568 |
| Gene | ACTL8 |
| Organism | Homo sapiens |
| Length | 366 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.32
- major depressive disorder · score 0.32
- neuroticism measurement · score 0.14
- lung adenocarcinoma · score 0.08
- triple-negative breast cancer · score 0.07
- head and neck squamous cell carcinoma · score 0.07
- breast carcinoma · score 0.05
- neoplasm · score 0.03
- lymphocyte count · score 0.03
- oral squamous cell carcinoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H568-F1 | alphafold | PREDICTED | 88.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H568.
Amino-acid sequence (366 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACTL8?
The strongest Open Targets associations for ACTL8 are protein measurement, major depressive disorder, neuroticism measurement, lung adenocarcinoma and triple-negative breast cancer.
How long is the ACTL8 protein?
The Homo sapiens ACTL8 protein (UniProt Q9H568) is 366 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H568 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H568 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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