Piezo-type mechanosensitive ion channel component 2 (PIEZO2)
Homo sapiens — UniProt Q9H5I5
Data last refreshed: (UniProt release unknown)
Key facts
Piezo-type mechanosensitive ion channel component 2 (PIEZO2) is a protein from Homo sapiens identified by UniProt accession Q9H5I5, 2752 residues long. MolForge cross-references it against 0 known binders and 203 disease associations.
- UniProt accession: Q9H5I5; gene symbol PIEZO2.
- Organism: Homo sapiens.
- Length: 2752 amino acids.
- Target class: Ion channel.
- Top disease associations (Open Targets): Arthrogryposis with oculomotor limitation and electroretinal anomalies, arthrogryposis- oculomotor limitation-electroretinal anomalies syndrome and Gordon syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Piezo-type mechanosensitive ion channel component 2 |
|---|---|
| UniProt accession | Q9H5I5 |
| Gene | PIEZO2 |
| Organism | Homo sapiens |
| Length | 2752 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Ion channel (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (203)
Diseases linked to this target (Open Targets).
- Arthrogryposis with oculomotor limitation and electroretinal anomalies · score 0.79
- arthrogryposis- oculomotor limitation-electroretinal anomalies syndrome · score 0.75
- Gordon syndrome · score 0.74
- distal arthrogryposis · score 0.66
- Marden-Walker syndrome · score 0.64
- genetic disorder · score 0.53
- fetal akinesia deformation sequence · score 0.45
- arthrogryposis multiplex congenita · score 0.45
- fetal akinesia deformation sequence 1 · score 0.45
- diastolic blood pressure · score 0.44
3D Structure (8)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H5I5-F2 | alphafold | PREDICTED | 77.47 | — |
| AF-Q9H5I5-F1 | alphafold | PREDICTED | 77.29 | — |
| AF-Q9H5I5-F3 | alphafold | PREDICTED | 74.03 | — |
| AF-Q9H5I5-F6 | alphafold | PREDICTED | 73.84 | — |
| AF-Q9H5I5-F4 | alphafold | PREDICTED | 73.55 | — |
| AF-Q9H5I5-F7 | alphafold | PREDICTED | 72.83 | — |
| AF-Q9H5I5-F8 | alphafold | PREDICTED | 71.62 | — |
| AF-Q9H5I5-F5 | alphafold | PREDICTED | 71.55 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H5I5.
Amino-acid sequence (2752 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIEZO2?
The strongest Open Targets associations for PIEZO2 are Arthrogryposis with oculomotor limitation and electroretinal anomalies, arthrogryposis- oculomotor limitation-electroretinal anomalies syndrome, Gordon syndrome, distal arthrogryposis and Marden-Walker syndrome.
How long is the PIEZO2 protein?
The Homo sapiens PIEZO2 protein (UniProt Q9H5I5) is 2752 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H5I5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H5I5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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