Protein O-mannose kinase (POMK)
Homo sapiens — UniProt Q9H5K3
Data last refreshed: (UniProt release unknown)
Key facts
Protein O-mannose kinase (POMK) is a protein from Homo sapiens identified by UniProt accession Q9H5K3, 350 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.
- UniProt accession: Q9H5K3; gene symbol POMK.
- Organism: Homo sapiens.
- Length: 350 amino acids.
- Target class: Kinase.
- Top disease associations (Open Targets): muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 12, limb-girdle muscular dystrophy due to POMK deficiency and muscular dystrophy-dystroglycanopathy (limb-girdle), type c, 12.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein O-mannose kinase |
|---|---|
| UniProt accession | Q9H5K3 |
| Gene | POMK |
| Organism | Homo sapiens |
| Length | 350 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Kinase (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (87)
Diseases linked to this target (Open Targets).
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 12 · score 0.81
- limb-girdle muscular dystrophy due to POMK deficiency · score 0.70
- muscular dystrophy-dystroglycanopathy (limb-girdle), type c, 12 · score 0.55
- muscular dystrophy-dystroglycanopathy, type A · score 0.38
- congenital muscular dystrophy with cerebellar involvement · score 0.37
- genetic disorder · score 0.19
- eosinophil count · score 0.14
- prostate carcinoma · score 0.13
- protein measurement · score 0.10
- eosinophil percentage of leukocytes · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H5K3-F1 | alphafold | PREDICTED | 91.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H5K3.
Amino-acid sequence (350 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POMK?
The strongest Open Targets associations for POMK are muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type a, 12, limb-girdle muscular dystrophy due to POMK deficiency, muscular dystrophy-dystroglycanopathy (limb-girdle), type c, 12, muscular dystrophy-dystroglycanopathy, type A and congenital muscular dystrophy with cerebellar involvement.
How long is the POMK protein?
The Homo sapiens POMK protein (UniProt Q9H5K3) is 350 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H5K3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H5K3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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