DNA transposase THAP9 (THAP9)
Homo sapiens — UniProt Q9H5L6
Data last refreshed: (UniProt release unknown)
Key facts
DNA transposase THAP9 (THAP9) is a protein from Homo sapiens identified by UniProt accession Q9H5L6, 903 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q9H5L6; gene symbol THAP9.
- Organism: Homo sapiens.
- Length: 903 amino acids.
- Top disease associations (Open Targets): Red cell distribution width, IGF-1 measurement and bone density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA transposase THAP9 |
|---|---|
| UniProt accession | Q9H5L6 |
| Gene | THAP9 |
| Organism | Homo sapiens |
| Length | 903 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.38
- IGF-1 measurement · score 0.31
- bone density · score 0.31
- urate measurement · score 0.31
- lymphocyte percentage of leukocytes · score 0.25
- neutrophil percentage of leukocytes · score 0.21
- apolipoprotein A 1 measurement · score 0.18
- hypertension · score 0.15
- leukocyte count · score 0.14
- neutrophil-to-lymphocyte ratio · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H5L6-F1 | alphafold | PREDICTED | 73.49 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H5L6.
Amino-acid sequence (903 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THAP9?
The strongest Open Targets associations for THAP9 are Red cell distribution width, IGF-1 measurement, bone density, urate measurement and lymphocyte percentage of leukocytes.
How long is the THAP9 protein?
The Homo sapiens THAP9 protein (UniProt Q9H5L6) is 903 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H5L6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H5L6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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