Rab GTPase-binding effector protein 2 (RABEP2)
Homo sapiens — UniProt Q9H5N1
Data last refreshed: (UniProt release unknown)
Key facts
Rab GTPase-binding effector protein 2 (RABEP2) is a protein from Homo sapiens identified by UniProt accession Q9H5N1, 569 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.
- UniProt accession: Q9H5N1; gene symbol RABEP2.
- Organism: Homo sapiens.
- Length: 569 amino acids.
- Top disease associations (Open Targets): common variable immunodeficiency, genetic disorder and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rab GTPase-binding effector protein 2 |
|---|---|
| UniProt accession | Q9H5N1 |
| Gene | RABEP2 |
| Organism | Homo sapiens |
| Length | 569 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (55)
Diseases linked to this target (Open Targets).
- common variable immunodeficiency · score 0.48
- genetic disorder · score 0.19
- body mass index · score 0.12
- Brody myopathy · score 0.12
- myoepithelial tumor · score 0.11
- lymphocyte count · score 0.06
- waist circumference · score 0.04
- body fat percentage · score 0.04
- cognitive function measurement · score 0.04
- smoking behavior · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H5N1-F1 | alphafold | PREDICTED | 77.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H5N1.
Amino-acid sequence (569 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RABEP2?
The strongest Open Targets associations for RABEP2 are common variable immunodeficiency, genetic disorder, body mass index, Brody myopathy and myoepithelial tumor.
How long is the RABEP2 protein?
The Homo sapiens RABEP2 protein (UniProt Q9H5N1) is 569 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H5N1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H5N1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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