Dimethyladenosine transferase 2, mitochondrial (TFB2M)
Homo sapiens — UniProt Q9H5Q4
Data last refreshed: (UniProt release unknown)
Key facts
Dimethyladenosine transferase 2, mitochondrial (TFB2M) is a protein from Homo sapiens identified by UniProt accession Q9H5Q4, 396 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q9H5Q4; gene symbol TFB2M.
- Organism: Homo sapiens.
- Length: 396 amino acids.
- Top disease associations (Open Targets): hemolysis, neoplasm and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Dimethyladenosine transferase 2, mitochondrial |
|---|---|
| UniProt accession | Q9H5Q4 |
| Gene | TFB2M |
| Organism | Homo sapiens |
| Length | 396 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- hemolysis · score 0.30
- neoplasm · score 0.07
- hepatocellular carcinoma · score 0.04
- metabolite measurement · score 0.03
- acute myeloid leukemia · score 0.02
- ovarian neoplasm · score 0.01
- IGA glomerulonephritis · score 0.01
- parkinsonism-dystonia, infantile · score 0.01
- Infantile dystonia-parkinsonism · score 0.01
- non-small cell lung carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H5Q4-F1 | alphafold | PREDICTED | 80.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H5Q4.
Amino-acid sequence (396 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TFB2M?
The strongest Open Targets associations for TFB2M are hemolysis, neoplasm, hepatocellular carcinoma, metabolite measurement and acute myeloid leukemia.
How long is the TFB2M protein?
The Homo sapiens TFB2M protein (UniProt Q9H5Q4) is 396 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H5Q4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H5Q4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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