Zinc finger protein Pegasus (IKZF5)
Homo sapiens — UniProt Q9H5V7
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein Pegasus (IKZF5) is a protein from Homo sapiens identified by UniProt accession Q9H5V7, 419 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.
- UniProt accession: Q9H5V7; gene symbol IKZF5.
- Organism: Homo sapiens.
- Length: 419 amino acids.
- Top disease associations (Open Targets): thrombocytopenia 7, Thrombocytopenia and autosomal thrombocytopenia with normal platelets.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein Pegasus |
|---|---|
| UniProt accession | Q9H5V7 |
| Gene | IKZF5 |
| Organism | Homo sapiens |
| Length | 419 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (22)
Diseases linked to this target (Open Targets).
- thrombocytopenia 7 · score 0.60
- Thrombocytopenia · score 0.47
- autosomal thrombocytopenia with normal platelets · score 0.37
- 2-methylbutyryl-CoA dehydrogenase deficiency · score 0.15
- Kallmann syndrome · score 0.04
- ulcerative colitis · score 0.04
- melorheostosis · score 0.04
- autosomal recessive hypophosphatemic rickets · score 0.04
- hyperostosis corticalis generalisata · score 0.03
- ghosal hematodiaphyseal dysplasia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H5V7-F1 | alphafold | PREDICTED | 53.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H5V7.
Amino-acid sequence (419 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IKZF5?
The strongest Open Targets associations for IKZF5 are thrombocytopenia 7, Thrombocytopenia, autosomal thrombocytopenia with normal platelets, 2-methylbutyryl-CoA dehydrogenase deficiency and Kallmann syndrome.
How long is the IKZF5 protein?
The Homo sapiens IKZF5 protein (UniProt Q9H5V7) is 419 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H5V7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H5V7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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