Cytosolic iron-sulfur assembly component 2A (CIAO2A)
Homo sapiens — UniProt Q9H5X1
Data last refreshed: (UniProt release unknown)
Key facts
Cytosolic iron-sulfur assembly component 2A (CIAO2A) is a protein from Homo sapiens identified by UniProt accession Q9H5X1, 160 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q9H5X1; gene symbol CIAO2A.
- Organism: Homo sapiens.
- Length: 160 amino acids.
- Top disease associations (Open Targets): cystitis, erythrocyte count and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytosolic iron-sulfur assembly component 2A |
|---|---|
| UniProt accession | Q9H5X1 |
| Gene | CIAO2A |
| Organism | Homo sapiens |
| Length | 160 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- cystitis · score 0.18
- erythrocyte count · score 0.17
- hemoglobin measurement · score 0.06
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.06
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.06
- primary familial polycythemia due to EPO receptor mutation · score 0.06
- Pyruvate kinase hyperactivity · score 0.06
- red blood cell density measurement · score 0.05
- macrothrombocytopenia, isolated, 2, autosomal dominant · score 0.05
- neoplasm · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H5X1-F1 | alphafold | PREDICTED | 86.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H5X1.
Amino-acid sequence (160 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CIAO2A?
The strongest Open Targets associations for CIAO2A are cystitis, erythrocyte count, hemoglobin measurement, Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 and alpha thalassemia-intellectual disability syndrome type 1.
How long is the CIAO2A protein?
The Homo sapiens CIAO2A protein (UniProt Q9H5X1) is 160 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H5X1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H5X1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.