Probable ATP-dependent RNA helicase DHX35 (DHX35)
Homo sapiens — UniProt Q9H5Z1
Data last refreshed: (UniProt release unknown)
Key facts
Probable ATP-dependent RNA helicase DHX35 (DHX35) is a protein from Homo sapiens identified by UniProt accession Q9H5Z1, 703 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q9H5Z1; gene symbol DHX35.
- Organism: Homo sapiens.
- Length: 703 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, bone density and urate measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DHX35 |
|---|---|
| UniProt accession | Q9H5Z1 |
| Gene | DHX35 |
| Organism | Homo sapiens |
| Length | 703 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- bone density · score 0.25
- urate measurement · score 0.25
- sex hormone-binding globulin measurement · score 0.21
- basal cell carcinoma · score 0.14
- protein measurement · score 0.14
- body height · score 0.11
- appendicular lean mass · score 0.11
- venous thromboembolism · score 0.11
- nose morphology measurement · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H5Z1-F1 | alphafold | PREDICTED | 86.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H5Z1.
Amino-acid sequence (703 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DHX35?
The strongest Open Targets associations for DHX35 are neurodegenerative disease, bone density, urate measurement, sex hormone-binding globulin measurement and basal cell carcinoma.
How long is the DHX35 protein?
The Homo sapiens DHX35 protein (UniProt Q9H5Z1) is 703 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H5Z1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H5Z1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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