ATP-dependent DNA helicase PIF1 (PIF1)
Homo sapiens — UniProt Q9H611
Data last refreshed: (UniProt release unknown)
Key facts
ATP-dependent DNA helicase PIF1 (PIF1) is a protein from Homo sapiens identified by UniProt accession Q9H611, 641 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q9H611; gene symbol PIF1.
- Organism: Homo sapiens.
- Length: 641 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, genetic disorder and pulse pressure measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATP-dependent DNA helicase PIF1 |
|---|---|
| UniProt accession | Q9H611 |
| Gene | PIF1 |
| Organism | Homo sapiens |
| Length | 641 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.36
- genetic disorder · score 0.12
- pulse pressure measurement · score 0.10
- nonpapillary renal cell carcinoma · score 0.08
- platelet count · score 0.08
- mean platelet volume · score 0.07
- lung adenocarcinoma · score 0.06
- non-small cell lung carcinoma · score 0.05
- platelet component distribution width · score 0.05
- neoplasm · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H611-F1 | alphafold | PREDICTED | 77.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H611.
Amino-acid sequence (641 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIF1?
The strongest Open Targets associations for PIF1 are neurodegenerative disease, genetic disorder, pulse pressure measurement, nonpapillary renal cell carcinoma and platelet count.
How long is the PIF1 protein?
The Homo sapiens PIF1 protein (UniProt Q9H611) is 641 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H611 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H611 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.