Ribonuclease P protein subunit p21 (RPP21)
Homo sapiens — UniProt Q9H633
Data last refreshed: (UniProt release unknown)
Key facts
Ribonuclease P protein subunit p21 (RPP21) is a protein from Homo sapiens identified by UniProt accession Q9H633, 154 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.
- UniProt accession: Q9H633; gene symbol RPP21.
- Organism: Homo sapiens.
- Length: 154 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, anxiety measurement and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ribonuclease P protein subunit p21 |
|---|---|
| UniProt accession | Q9H633 |
| Gene | RPP21 |
| Organism | Homo sapiens |
| Length | 154 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (27)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- anxiety measurement · score 0.33
- mean corpuscular volume · score 0.17
- mosquito bite reaction itch intensity measurement · score 0.13
- MHC class I polypeptide-related sequence B measurement · score 0.09
- self reported educational attainment · score 0.06
- neutrophil-to-lymphocyte ratio · score 0.05
- eosinophil count · score 0.04
- lung carcinoma · score 0.04
- hepatocellular carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H633-F1 | alphafold | PREDICTED | 81.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H633.
Amino-acid sequence (154 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RPP21?
The strongest Open Targets associations for RPP21 are neurodegenerative disease, anxiety measurement, mean corpuscular volume, mosquito bite reaction itch intensity measurement and MHC class I polypeptide-related sequence B measurement.
How long is the RPP21 protein?
The Homo sapiens RPP21 protein (UniProt Q9H633) is 154 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H633 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H633 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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