tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial (NSUN3)
Homo sapiens — UniProt Q9H649
Data last refreshed: (UniProt release unknown)
Key facts
tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial (NSUN3) is a protein from Homo sapiens identified by UniProt accession Q9H649, 340 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: Q9H649; gene symbol NSUN3.
- Organism: Homo sapiens.
- Length: 340 amino acids.
- Top disease associations (Open Targets): combined oxidative phosphorylation deficiency 48, genetic disorder and self reported educational attainment.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial |
|---|---|
| UniProt accession | Q9H649 |
| Gene | NSUN3 |
| Organism | Homo sapiens |
| Length | 340 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation deficiency 48 · score 0.70
- genetic disorder · score 0.41
- self reported educational attainment · score 0.31
- body fat percentage · score 0.28
- body mass index · score 0.27
- lean body mass · score 0.27
- fat body mass · score 0.26
- body weight · score 0.24
- blood protein measurement · score 0.23
- metabolite measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H649-F1 | alphafold | PREDICTED | 90.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H649.
Amino-acid sequence (340 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NSUN3?
The strongest Open Targets associations for NSUN3 are combined oxidative phosphorylation deficiency 48, genetic disorder, self reported educational attainment, body fat percentage and body mass index.
How long is the NSUN3 protein?
The Homo sapiens NSUN3 protein (UniProt Q9H649) is 340 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H649 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H649 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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