DENN domain-containing protein 2D (DENND2D)
Homo sapiens — UniProt Q9H6A0
Data last refreshed: (UniProt release unknown)
Key facts
DENN domain-containing protein 2D (DENND2D) is a protein from Homo sapiens identified by UniProt accession Q9H6A0, 471 residues long. MolForge cross-references it against 0 known binders and 61 disease associations.
- UniProt accession: Q9H6A0; gene symbol DENND2D.
- Organism: Homo sapiens.
- Length: 471 amino acids.
- Top disease associations (Open Targets): mean platelet volume, FEV/FVC ratio and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DENN domain-containing protein 2D |
|---|---|
| UniProt accession | Q9H6A0 |
| Gene | DENND2D |
| Organism | Homo sapiens |
| Length | 471 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (61)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.41
- FEV/FVC ratio · score 0.36
- platelet count · score 0.36
- reticulocyte count · score 0.36
- forced expiratory volume · score 0.34
- neurodegenerative disease · score 0.31
- reticulocyte measurement · score 0.29
- HbA1c measurement · score 0.28
- aspartate aminotransferase measurement · score 0.27
- platelet crit · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6A0-F1 | alphafold | PREDICTED | 84.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6A0.
Amino-acid sequence (471 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DENND2D?
The strongest Open Targets associations for DENND2D are mean platelet volume, FEV/FVC ratio, platelet count, reticulocyte count and forced expiratory volume.
How long is the DENND2D protein?
The Homo sapiens DENND2D protein (UniProt Q9H6A0) is 471 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6A0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6A0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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