Epoxide hydrolase 3 (EPHX3)
Homo sapiens — UniProt Q9H6B9
Data last refreshed: (UniProt release unknown)
Key facts
Epoxide hydrolase 3 (EPHX3) is a protein from Homo sapiens identified by UniProt accession Q9H6B9, 360 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q9H6B9; gene symbol EPHX3.
- Organism: Homo sapiens.
- Length: 360 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, mean corpuscular hemoglobin and platelet crit.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Epoxide hydrolase 3 |
|---|---|
| UniProt accession | Q9H6B9 |
| Gene | EPHX3 |
| Organism | Homo sapiens |
| Length | 360 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.21
- mean corpuscular hemoglobin · score 0.20
- platelet crit · score 0.14
- platelet count · score 0.09
- head and neck squamous cell carcinoma · score 0.07
- Down syndrome · score 0.05
- Red cell distribution width · score 0.04
- reticulocyte count · score 0.04
- reticulocyte measurement · score 0.04
- cancer · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6B9-F1 | alphafold | PREDICTED | 94.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6B9.
Amino-acid sequence (360 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EPHX3?
The strongest Open Targets associations for EPHX3 are mean corpuscular volume, mean corpuscular hemoglobin, platelet crit, platelet count and head and neck squamous cell carcinoma.
How long is the EPHX3 protein?
The Homo sapiens EPHX3 protein (UniProt Q9H6B9) is 360 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6B9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6B9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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