XK-related protein 8 (XKR8)
Homo sapiens — UniProt Q9H6D3
Data last refreshed: (UniProt release unknown)
Key facts
XK-related protein 8 (XKR8) is a protein from Homo sapiens identified by UniProt accession Q9H6D3, 395 residues long. MolForge cross-references it against 0 known binders and 126 disease associations.
- UniProt accession: Q9H6D3; gene symbol XKR8.
- Organism: Homo sapiens.
- Length: 395 amino acids.
- Top disease associations (Open Targets): erythrocyte count, azoospermia and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | XK-related protein 8 |
|---|---|
| UniProt accession | Q9H6D3 |
| Gene | XKR8 |
| Organism | Homo sapiens |
| Length | 395 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (126)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.10
- azoospermia · score 0.09
- neoplasm · score 0.08
- partial chromosome Y deletion · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- congenital bilateral absence of vas deferens · score 0.06
- spermatogenic failure 25 · score 0.06
- spinocerebellar ataxia type 32 · score 0.06
- isochromosomy Yp · score 0.06
- isolated congenital hypogonadotropic hypogonadism · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H6D3-F1 | alphafold | PREDICTED | 82.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H6D3.
Amino-acid sequence (395 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with XKR8?
The strongest Open Targets associations for XKR8 are erythrocyte count, azoospermia, neoplasm, partial chromosome Y deletion and male infertility with teratozoospermia due to single gene mutation.
How long is the XKR8 protein?
The Homo sapiens XKR8 protein (UniProt Q9H6D3) is 395 amino acids long.
Browse: Targets: X · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H6D3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H6D3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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